China scientist claims world’s first gene-edited babies

Hong Kong, China | AFP | A scientist in China claims to have created the world’s first genetically-edited babies, a move that would be a ground-breaking medical first but which has generated a barrage of criticism.

Chinese university professor He Jiankui posted a video on YouTube saying that the twin girls, born a few weeks ago, had had their DNA altered to prevent them from contracting HIV.

The professor, who was educated at Stanford in the US and works from a lab in the southern Chinese city of Shenzhen, said their DNA was modified using CRISPR, a technique which allows scientists to remove and replace a strand with pinpoint precision.

The development emerged Sunday in an article published by industry journal the MIT Technology Review, which referenced medical documents posted online by He’s research team to recruit couples for the experiments.

He’s video then went online, prompting a heated debate among the scientific community, including from experts who cast doubt over the claimed breakthrough, and others who decried it as a modern form of eugenics.

He said the babies, known as “Lulu” and “Nana” although they are not their real names, were born through regular IVF but using an egg which was specially modified before being inserted into the womb.

“Right after sending her husband’s sperm into her egg, an embryologist also sent in CRISPR/Cas9 protein and instructions to perform a gene surgery intended to protect the girls from future HIV infection,” he said.

Gene editing is a potential fix for heritable diseases but it is extremely controversial because the changes would be passed down to future generations and could eventually affect the entire gene pool.

The MIT Technology Review warned “the technology is ethically charged”.

The claims come ahead of a conference of world experts in Hong Kong this week, with He expected to speak on Wednesday and Thursday.

But there is as yet no independent verification of his claims, which have not been published in a peer-reviewed journal — an omission that the scientist’s critics have seized on.

– ‘Highly problematic’ –

The research has been robustly criticised by Chinese scientists and institutions. The university where He works said he had been on unpaid leave since February and his research is a “serious violation of academic ethics and norms”.

“This research work was carried out by Professor He Jiankui outside of the school,” the Southern University of Science and Technology said in a statement Monday.

And a joint statement from a group of 100 scientists in China criticised the findings and called for better state legislation.

“It is a great blow to the global reputation and development of biomedical research in China,” said the statement posted on social media platform Weibo.

“It is extremely unfair to the vast majority of Chinese scholars who are diligent in scientific research and innovation.”

Other scientists all around the world were also critical, with some saying a YouTube video was an inadequate way of announcing scientific findings, and others warning that exposing healthy embryos and children to gene editing was irresponsible.

Professor Joyce Harper, professor in genetics and human embryology at London’s UCL, said: “Today’s report of genome editing human embryos for resistance to HIV is premature, dangerous and irresponsible.”

The issue of editing human DNA is highly controversial, and only allowed in the US in laboratory research — although US scientists said last year that they had successfully edited the genetic code of piglets to remove dormant viral infections.

But this is not the first time Chinese researchers have experimented with human embryo technology, and last September scientists at Sun Yat-sen University used an adapted version of gene-editing to correct a disease-causing mutation in human embryos.