Khan insisted the England national team would still be able to use Wembley as their home venue, while the FA and League Cup finals would also continue to be played there.
“We are very happy for Shahid Khan and the Jacksonville Jaguars,” the NFL said in a statement.
“The potential purchase of Wembley Stadium is a further powerful sign of their commitment to the UK and their vision to help us grow the sport.
“Having stadium options in London has always been critical to the NFL and, in tandem with our 10-year partnership with Tottenham Hotspur, this new relationship would allow for even greater flexibility in scheduling future NFL games in London.”
It is believed the FA are considering the deal because the money raised would be ring-fenced for investment in grass-roots programmes they feel are essential for football’s future in the United Kingdom.
One report says Glenn believes the sale would pay for 1,500 new full-sized all-weather artificial pitches across Britain.
The current version of Wembley, famous for its iconic arch, replaced the original venue, which was renowned for its twin towers on one side of the stadium.
Wembley has staged the FA Cup final since the old stadium opened in 1923 and has hosted some of football’s most celebrated matches, including England’s 1966 World Cup final victory and seven European Cup finals.